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The copper ion is essential for biological activity the apo-peptide (GHK without copper) shows markedly reduced activity in most assay systems
01Mechanism of action The mechanism of GHK-Cu articulates around three axes: copper chelation, extracellular matrix remodelling, and massive transcriptional modulation
Background Selective delivery of chemotherapeutic agents to cancer cells to ensure the effectiveness of treatment while minimizing damage to healthy tissue is one of the most important aspects of cancer therapy [1,2,3]
Summary Interpretation The most defensible interpretation is that 5-Amino-1MQ is a small-molecule NNMT inhibitor that has been used in published preclinical research models without prominent severe acute toxicological signals described in the cited preclinical model reports under their specific tested conditions
