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A certain negative role in the development of complications is taken by irrational external therapy, in particular long-lasting uncontrolled applications of external corticosteroid preparations

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These structural and functional observations have been integrated under the broader concept of thalamocortical dysrhythmia, in which persistent alterations in thalamic output and thalamocortical rhythms are thought to contribute to interictal features of migraine such as deficient habituation and multisensory hypersensitivity [35]

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