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For the treatment regimen estimand, all tirzepatide doses were associated with numerically higher odds of participants with prediabetes achieving reversal versus liraglutide and semaglutide (Supplementary Material Table S8), although the higher proportion of patients with prediabetes achieving reversal in the placebo arm of SURMOUNT-1 compared with SCALE and STEP 1 suggests that the relative efficacy of tirzepatide versus liraglutide and semaglutide may be underestimated (Supplementary Material Table S4)

Intermittent fasting can also help harmonise insulin levels and promote the body's own GLP-1 production

Qiu J, Bosch MA, Zhang C, Rnnekleiv OK, Kelly MJ

glucagon receptor activation boosts thermogenesis and energy expenditure

What Is Microdosing GLP-1