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Weeks 12: 2 mg once weekly Weeks 34: 4 mg once weekly Weeks 58: 8 mg once weekly Week 9+: 12 mg once weekly Efficacy and safety: The reason for the slow and gradual dosing protocol The Phase 2 clinical trial of retatrutide demonstrated that participants receiving the highest dose (12 mg) achieved up to 24% weight reduction after 48 weeks

Among the 5,442 GI adverse events reported to the FDA, eructation had a reporting odds ratio of 42.03

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Ojeniran M et al

10.1016/j.physbeh.2018.12.002 95 FeterN.SchaunG