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Glucagon increases energy expenditure independently of brown adipose tissue activation in humans

In science, a finding is not considered established until it has been independently replicated, meaning a different lab with different researchers, different equipment, and no financial connection to the original team gets the same result

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Furthermore, recent studies point to possible protection against macular degeneration and heart disease by lowering homocysteine levels

However if you do not feel any effect, like a boost in energy levels, feel free to up the dosage