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The compound is still working through Eli Lilly's TRIUMPH Phase 3 program, with seven additional trial readouts expected through 2026 alongside the already-reported TRIUMPH-4 data from December 2025
doi: 10.1016/j.jplph.2014.12.014 4 ChenI
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Note that semaglutide is very similar to GLP-1 and its mechanism of action is therefore limited to the activation of the receptor for this hormone, while tirzepatide is made up of an amalgam of amino acids found both in the GLP-1 (yellow circles), GIP (blue circles), and in the two hormones (green circles), which gives it a double agonist activity, capable of activating both receptors for these hormones
