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Activation of TRPV1 mediates calcitonin gene-related peptide release, which excites trigeminal sensory neurons and is attenuated by a retargeted botulinum toxin with anti-nociceptive potential

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But understanding why this happens with semaglutide, tirzepatide and other GLP-1 drugs could be crucial to understanding their longer-term health consequences and how best to prescribe them in future

However, it is still not approved for cosmetic tanning, and safety considerations remain similar