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The observation of senescent cells in in vitro expanded chondrocytes have been reported as early as 2002

doi: 10.1126/science.abb8034 22 GiardiniV.CarrerA.CasatiM.ControE.VerganiP.Gambacorti-PasseriniC

Mechanistic studies examine its interactions with nitric oxide signaling, prostaglandin pathways, and gastrointestinal dopamine and serotonin turnover, including their relevance to experimental models of intestinal inflammation and gastrointestinal dysfunction

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To put that in perspective, the best semaglutide clinical trials showed approximately 15-17% weight reduction, and tirzepatide results peaked around 20-22%