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Systemic action requires the peptide to reach the bloodstream and travel to distant tissues muscle, tendon, brain, adipose tissue, or metabolic organs
Artemisinin has been shown to inhibit the NF-B signaling pathway, regulate inflammatory cytokine expression, and maintain intestinal barrier integrity by downregulating MUC2 and claudin-1 in the colonic mucosa, thereby suppressing DSS-induced colonic inflammation (165)
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