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It took persistence and some lucky timing at a conference (ADA 1996) for Eng to connect with Amylin Pharmaceuticals , a small biotech, which recognized the potential and licensed exendin-4 ( [56] ) ( [57] )

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Also, rapid desensitization of surface receptors that are prevented from entering the endocytic pathway may be less relevant with agonists such as exendin-phe1, for which -arrestin recruitment is markedly reduced