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Clinical trials show no serious side effects
GLP-1 receptor agonists and GIP/GLP-1 dual agonists carry a deep trial record: STEP studied semaglutide for weight management (NEJM 2021), SURMOUNT studied tirzepatide for weight management (NEJM 2022), and SURMOUNT-OSA studied tirzepatide for obstructive sleep apnea (NEJM 2024)
Slight differences in endpoints, assessment tools, and statistical power could have shifted results
More insulin than your body requires leads to hypoglycemia episodes and high rebounds
W., Schoenherr, J., Gouker, L
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