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A 2026 Oxford University meta-analysis found patients regained approximately 0.8 kg per month after stopping newer GLP-1 drugs, with most returning to baseline weight within 1.5 years

Nearly 90% of participants remained on the medication after 72 weeks

Prescription GLP-1 drugs work by binding directly to GLP-1 receptors and activating them at a level the body cant produce on its ownwhich is why they can lead to powerful, sustained appetite suppression

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At this body weight, the milligram-per-kilogram exposure is significantly higher than for heavier participants