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Elevated Th17/Treg ratios and IL-17R-mediated NF-B activation have been documented in HT thyroid tissue (Ruggeri et al., 2014

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Second, the specificity claims come predominantly from the originating research network, so independent confirmation is limited

35 Two similar trials, each including 109 perimenopausal women, found that 4 mg of Siberian rhubarb extract daily reduced hot flashes, anxiety symptoms, and total menopausal symptom scores, and improved overall health and well-being more effectively than placebo after 12 weeks

In general, the actual mechanisms that induce autoimmune disease pathogenesis are complicated and might involve far more molecules and signaling pathways