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It is the body's primary intracellular antioxidant, operating in both the cytosol and mitochondria, and is directly responsible for regenerating Vitamin C, Vitamin E, and alpha lipoic acid

Endocrinology 149 (5), 20382047

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In the following sections, we will elaborate on the specific impacts of two major therapeutic approachesvaricocele ligation surgery and adjuvant therapy with antioxidants or anti-inflammatory agentson immune-inflammatory interactions, as well as their potential molecular mechanisms and clinical implications