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Preclinical literature supports intermittent administration (23 times per week) rather than daily protocols, reducing the theoretical risk of receptor downregulation
Pediatr Res 81:113119
Key Areas of Research Structural: collagen, matrix, tendon Vascular: angiogenesis, nitric oxide, signaling Epithelial: migration, vessel formation, matrix Systemic: signaling, viability, pathway dynamics References Sikiric P
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