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While moderate ROS levels are involved in a spectrum of signaling pathways that are vital for cell growth, differentiation, and progression, elevated ROS levels are potent triggers of cell death [7]
However, because HGF/c-Met signaling also plays roles in cell proliferation and is implicated in certain cancers, the long-term safety implications of chronic c-Met activation require careful evaluation
This article is based on previously conducted studies and does not contain any new studies with human participants or animals performed by any of the authors
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