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Indeed, the European multicenter study coordinated by Graham reports that, whereas basal hyperhomocysteinemia only shows an additive effect with hypercholesterolemia, it has a synergistic effect with both hypertension and smoking on the incidence of atherosclerotic vascular disease (Graham et al, 1997)

Using the well-characterized 143B mitochondrial cybrid model 50 , we demonstrated that mtDNA mutant cells are more sensitive to 5FU treatment (Fig

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Murray MM, Michel CM, Grave de Peralta R, Ortigue S, Brunet D, Gonzalez Andino S et al (2004)