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Semaglutide, a long-acting GLP-1 receptor agonist with a half-life of approximately one week, has demonstrated significant efficacy across at least four distinct therapeutic indications, including type 2 diabetes mellitus, chronic weight management in adults with obesity or overweight, reduction of major adverse cardiovascular events in patients with established cardiovascular disease, and emerging indications in metabolic dysfunction-associated steatotic liver disease (MASLD)

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Kimble R, Keane KM, Lodge JK, Cheung W, Haskell-Ramsay CF, Howatson G

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