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Obesity can adversely affect reproductive health through various mechanisms, including hormonal imbalances, insulin resistance, and disruption of ovulatory cycles
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These cells then create clinically significant PCO when they migrate onto the posterior capsule due to both their intrinsic ability to scatter light and in fibrotic PCO, their ability to compromise lens capsule transparency via fibrotic ECM deposition and capsular wrinkling (49)
In diet-induced obesity models, this inhibition has been observed to reduce white fat accumulation and promote lipolysis, effectively reprogramming metabolic pathways toward enhanced energy expenditure
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