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You should also see a clinician if you have anemia symptoms, a history of gastric surgery, suspected pernicious anemia, or if lab testing hasnt confirmed a B12 deficiency.

Metabolic Rewiring: By stopping the conversion of nicotinamide (NAM) into 1-methylnicotinamide (1-MNA), the cell is forced to recycle NAM into NAD+

From a pharmacokinetic perspective, studies indicate no evidence that the combination of Vitamins B1, B6, and B12 adversely affects the pharmacokinetics of each individual vitamin

Moreover, vegetarians and vegans who may not consume enough B12-rich foods are at a higher risk of developing a deficiency