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Abbreviations GI: Gastrointestinal PDAC: Pancreatic ductal adenocarcinoma ECM: Extracellular matrix hpCAFs: Human pancreatic cancer associated fibroblasts TME: Tumor microenvironment LFD: Low fat diet HFD: High fat diet OGTT: Oral glucose tolerance test H&E: Hematoxilin/eosin PanIN: Pancreatic intraepithelial neoplasia NGS: Next generation sequencing SEMA: Semaglutide GO: Gene ontology NES: Normalized enrichment score CPTAC: Clinical proteomic tumor analysis consortium ND: Non-dysmetabolic D: Dysmetabolic TCGA: The cancer genome atlas GLP1: Glucagon like peptide 1 GLP1-RA: Glucagon like peptide 1 receptor agonist DEGs: Differentially expressed genes P4HA1: Prolyl 4-hydroxylase subunit alpha 1 E-cad: E-cadherin PanCK: Pancytokeratin aSMA: Alpha smooth muscle actin T2D: Type 2 diabetes GSEA: Gene Set Enrichment Analysis References Kassi E, Pervanidou P, Kaltsas G, Chrousos G
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The progressive load design was deliberately chosen to push participants to their maximal effort, ensuring that the effects of supplementation on endurance performance could be fully assessed under intense conditions
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