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Safety and evidence level: what is and isnt known In the mouse obesity study, systemic administration of the NNMT inhibitor reduced body weight, white-adipose mass and plasma cholesterol without changing food intake and without any observable adverse effects over the study period

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Most reported adverse events are local irritation or contact dermatitis, generally mild and self-limited

Dosing Conversations With Adolescent Patients and Families Adolescent patients aged 12, 17 have meaningful capacity to participate in shared decision-making about their own treatment, and the AAP recommends involving them directly in pharmacotherapy discussions [19]

Maintain accurate labeling and documentation for all stored research compounds