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Current estimates suggest: Approximately 900,000 people living with dementia in the UK (Alzheimer's Society) Two-thirds of these have Alzheimer's disease (approximately 600,000 people) Projected to rise to 1.6 million by 2040 as the population ages Healthcare and social care costs exceed 26 billion annually Informal caregiving burden is enormous, affecting family members' employment and wellbeing This disease burden explains why the NHS and research community continue pursuing disease-modifying treatments, despite repeated setbacks like the LIFT-AD trial failure

RCT SCALE Study - Liraglutide vs Placebo for Weight Loss in Overweight Nondiabetic Adults, NEJM (2015) [PubMed abstract] The SCALE study enrolled 3731 overweight adults who did not have diabetes Main inclusion criteria BMI 30

If you are exploring this approach, doing so under direct medical supervision is essential

How To Stay Strong on a GLP-1 Key takeaways: Whenever a person loses body fat, they also lose a smaller, proportional amount of lean mass including muscle mass

Gelam honey markedly inhibited these pathways in HIT-T15 pancreatic islet cells at concentrations as low as 20 g/mL (102)