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But for reproductive-age men who may want children, the standard first-line prescription of TRT deserves reconsideration in light of both the fertility risk it carries and the growing evidence that addressing the metabolic cause may be both safer and more effective

The Researching Cardiovascular Events with a Weekly Incretin in Diabetes (REWIND) trial focused on adults aged 50 years with either established or newly diagnosed type 2 diabetes and additional cardiovascular risk factors, and this trial investigated subjects with HbA1c 9.5%, receiving up to two oral glucose-lowering drugs with or without basal insulin, and a body mass index of at least 23 kg/m 2

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However, it may take several months to see the full benefits of the medication

While some complications may improve with recovery, others can persist for years