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These changes cause cellular dysfunction, cell cycle arrest and senescence with consequent secretion of pro-inflammatory and pro-fibrotic factors such as interleukin-1 (IL-1) and IL-6, TGF-1 and matrix metalloproteinases (MMPs) [12, 13]

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Mol Cell (2007) 26(1):114.10.1016/j.molcel.2007.03.016 82 FabianiRSepportaMVMazzaTRosignoliPFuccelliRDe BartolomeoAet alInfluence of cultivar and concentration of selected phenolic constituents on the in vitro chemiopreventive potential of olive oil extracts

Based on this framework, the following sections will detail the specific mechanisms of ferroptosis in each respective disease

Cusi K, Isaacs S, Barb D, Basu R, Caprio S, Garvey WT, Kashyap S, Mechanick JI, Mouzaki M, Nadolsky K, Rinella ME, Vos MB, Younossi Z