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Nonsteroidal anti-inflammatory drugs (NSAIDs) inhibit cyclooxygenase enzymes broadly, affecting both COX-1 and COX-2 pathways with well-documented gastric and cardiovascular adverse events
However, vegans and strict vegetarians require particular attention, as plant-based foods contain negligible B12 unless fortified
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Digestive issues: Loss of appetite, weight loss, constipation, or diarrhea
Whether this pathway operates identically in adolescent adipose tissue, which carries a higher proportion of brown adipose tissue relative to adult depots, remains unstudied [7]
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