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The clinical data does not show tolerance development in the way that some other medications lose effectiveness over time
Rodents have shorter GLP-1 half-lives than humans semaglutide may require twice-weekly dosing in mice versus once-weekly in humans
This means people following restricted diets may be more likely to develop low levels over time
Although stress is also a factor which may influence insulin resistance, no doctor treating individuals with diabetes would consider that those needing higher doses of insulin are mentally unstable, making up their disease, or suffering from the placebo effect
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