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NNMT plays a key role in regulating energy metabolism and fat storage

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Gastrointestinal surgery can also affect B12 absorption

Given that both diet composition and adiposity can each substantially impact the gut microflora in obese mice 24 , we conducted a secondary endpoint study using animals given the same series of diets to test the hypothesis that NNMTi treatment combined with LD, but not LD alone, shifts the cecal microbiome profile of obese animals to be similar to age-matched LD controls that were never given a high-fat diet

It is typically not recommended for self-administration due to the smaller muscle mass compared to other sites