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(3) It is also suggested that the ARA-290 peptide may act primarily via this IRR-mediated pathway

Key molecular features include the F23 Cagri residue anchoring the peptide at the receptor transmembrane (TM) bundle level and the micelle, an E14-R17 intramolecular salt bridge enhancing helical stability, and C-terminal P37 Cagri interaction with the receptor ECD

B12 deficiency can worsen tinnitus and lead to other symptoms like fatigue, muscle weakness, and nerve damage