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Meeting highlights from the Pharmacovigilance Risk Assessment Committee (PRAC), 2326 October 2023 GLP-1 receptor agonists and thyroid cancer

The dosage and administration of GLP-1RAs for treatment is to draw 50 l of 6 mg/ml GLP-1RAs and inject it into the sole of each rats foot

This provides reassurance for combined therapy approaches, though individual risk assessment remains important

It functions as a cofactor for key enzymatic reactions involved in one-carbon metabolism, nucleic acid synthesis, and mitochondrial energy regulation

The FDA approved Mounjaro for type 2 diabetes in May 2022 and for chronic weight management (as Zepbound, same molecule) in November 2023