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Scrutiny increases in a good way: tighter guardrails on claims, stronger post-market QA, and fewer proprietary blends that promise too much
There was a significant between-study heterogeneity ( I 2 = 539 %, P = 0034) in which the study location and duration of studies were revealed as the sources of heterogeneity following subgroup analysis
A 2.5 mg dose from a 17 mg/mL vial requires only approximately 14.7 units, not 25
Like fentanyl, it is metabolized in the liver by CYP3A4 enzymes (12)
Reflecting this difficulty Novartis and Probiodrug had to abandon some of their early drug candidates because they proved unsafe and too toxic (Cordes)
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