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Studies show that around 68% of people who underwent a bariatric surgery such as gastric bypass reported a vitamin B12 deficiency
NNMT inhibition increases NAD+ levels and enhances sirtuin-mediated mitochondrial function
Studies testing doses up to 1 mg daily found no additional benefits above this threshold
They consider the patients health history, how severe the deficiency is, and any conditions that might affect how well the body absorbs B12
Oral vitamin B12 is often considered when diet is the suspected cause
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