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Neuroprotection : Preliminary research suggests GLP-1 RAs may have neuroprotective effects, with potential implications for treating Alzheimers disease (Holscher, 2020)
If you are scheduled for surgery, inform your anesthesia and surgical teams about your tirzepatide use, as delayed gastric emptying may increase aspiration risk during anesthesia
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This includes the possibility of Medicare coverage starting in 2026, which will provide further relief for senior patients
Other neuroprotective mechanisms potentially involved in the treatment of cognitive disorders as well as cerebrovascular disease and epilepsy suggest that GLP-1RAs can enhance the viability of neurons and restore neurite outgrowth by stimulating neurotrophic factors, thus increasing subventricular zone progenitor cells, decreasing apoptosis and the level of pro-inflammatory factors, and strengthening the bloodbrain barrier 37
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