1 For those taking Wegovy pill, 76% achieved 5% or greater body weight loss (from a baseline body weight of 235 lb.) versus 31% taking placebo (from a baseline body weight of 231 lb.)
GLP-1 agonists work by mimicking the action of the native hormone GLP-1, which is released after meals and engages a receptor (GLP-1R) that stimulates insulin release, suppresses glucagon, slows gastric emptying, and reduces appetite
These combined effects lower calorie intake without requiring willpower-based restriction, making sustainable weight loss more achievable
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