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These hormones play crucial roles in several physiological processes key to weight and blood sugar control: Insulin Secretion: Both GIP and GLP-1 stimulate the pancreas to release insulin in response to food intake, helping to lower blood sugar levels

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SURMOUNT-5 was open-label by necessity the two drugs use different injection devices and dose-escalation cadences but it stratified randomization by sex, prediabetes status, and BMI category ( 5 days, the label says skip and resume on your normal day