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Gastrointestinal Effects: Mild nausea, abdominal cramping, bloating, and flatulence may occur, especially during the initial supplementation period
A 2026 study comparing commercially administered NAD+ IV and nicotinamide-riboside IV offered preliminary short-term safety and tolerability information
10.1111/acel.13096 107 LiH.TangY.WenL.KongX.ChenX.LiuP.et al (2017a)
Common side effects of oral glutathione supplementation, when they occur, are typically mild and may include: Gastrointestinal symptoms such as bloating, cramping, or loose stools Mild allergic reactions, including skin rash Abdominal discomfort or nausea These effects are generally dose-dependent and often resolve with dose reduction or discontinuation
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