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10.1038/s41398-018-0093-y 86
The injection delivers B12 directly into the bloodstream, making it the most reliable method for patients with absorption problems, pernicious anaemia, or gastrointestinal conditions affecting B12 uptake (such as Crohn's disease, coeliac disease, or following gastric surgery)
Compounding pharmacies make customized medicines for individual patients, and under section 503A of the Food, Drug, and Cosmetic Act, a pharmacy can compound from a bulk substance only if that substance has an official quality monograph, is a component of an FDA-approved drug, or has been formally added to an approved bulks list. BPC-157 qualifies on none of those counts, which is why the FDA placed it in Category 2 of its 503A bulk-substance review in September of 2023
The primary reason is a process called metabolic adaptation, or adaptive thermogenesis
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