On other forums, I've seen a lot of folks complain about constipation
Effect of semaglutide on major adverse cardiovascular events by baseline kidney parameters in participants with type 2 diabetes and at high risk of cardiovascular disease: SUSTAIN 6 and PIONEER 6 post hoc pooled analysis
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Liver fat fraction, measured by MRI-PDFF in a subset of participants, fell by a mean of 81.2% in the 12 mg group at 24 weeks, consistent with the glucagon receptor component driving hepatic lipid oxidation [1, 6]
Individual response varies considerably, with some noticing effects earlier than others