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Short-acting GLP-1 receptor agonists typically have a more pronounced effect on gastric emptying than long-acting ones, and this effect may attenuate over time with continued treatment

Over time, stress, illness, and aging can disrupt this communication

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Most GLP-1R agonists have gastrointestinal side effects, including nausea, vomiting, diarrhea and constipation, which may be more pronounced in elderly patients with AD and affect treatment compliance