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Exposure to cigarette smoke can affect skin homeostasis due to oxidative and inflammatory reactions, as well as inducing lipid peroxidation, leading to increased levels of 4-HNE (113)

Deepmal, SlatteryJKumarNDelheyLBerkMDeanOet al

It is not a single-pathway molecule

Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, et al

Carnitine is most concentrated in tissues that use fatty acids as their primary fuel, such as skeletal and cardiac muscle because its required for mitochondrial beta-oxidation of long-chain fatty acids for energy production.1 Carnitine Deficiency and Dietary Sources The human body needs about 15 mg of carnitine per day from a combination of endogenous and dietary sources, and a typical omnivore diet provides up to 10 times that amount.2 Healthy individuals generally synthesize enough carnitine to prevent deficiency