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Regardless of these debates, people with chronic migraine are often cautious about taking too many acute medications, not only because of the risk of medication adaptation headache but because of potential side effects of the medications themselves or just not wanting to be reliant on drugs to get through the day

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Getting to the brain Trapp is working to fully understand how GLP-1 drugs work is still ongoing, particularly whether these peptide molecules penetrate the brain

TRIUMPH-4 Results (December 2025): The First Phase 3 Data TRIUMPH-4 was the first Phase 3 trial to read out and the first concrete look at retatrutide's efficacy outside the Phase 2 cohort

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