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Cagrilintide generally has a more favourable safety profile with lower rates of gastrointestinal side effects, though nausea and constipation can still occur

This deficit has made amylin receptor agonism a target of significant research interest as a complement to insulin and GLP-1 pathway modulation

Protocol: AOD-9604 500 mcg/day (split dose), 400-calorie daily deficit, resistance training 3 times per week

However, for reasons that are incompletely understood, in preclinical and clinical studies, adding either a GIPR agonist or GIPR antagonist to GLP-1R agonism causes additional weight loss 1

10.1038/s41380-020-0793-6 70 MairD.ParisA.ZaloumS