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Reported Side Effects: Injection site reactions (most common) Headache Mild water retention Transient dizziness Fatigue (temporary) Joint stiffness (with GH elevation) Rare/Serious (requiring immediate attention): Significant swelling of hands, feet, or face Chest pain or shortness of breath Vision changes Allergic reactions FDA Concerns: Immunogenicity risk Limited clinical safety data Classified as Category 2 bulk drug substance presenting significant safety risks Regulatory Status United States: Not FDA approved for any indication
Its one of the greatest concerns that people have, she said
doi: 10.1016/j.intimp.2025.114038
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Candidates typically fall into one of two groups: patients already running a broader anti-aging protocol who want to add a sleep and cellular renewal layer, or patients whose primary complaint is poor sleep quality and who want a protocol that addresses the underlying circadian biology rather than just supplementing melatonin
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