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LaccID was more stable than our starting template LacAnc100, with a T 50 (temperature at which the enzyme loses 50% of activity after 10 min of incubation) of 57.8 0.5 C compared to 54.8 0.2 C for LacAnc100 (Fig

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Primary carnitine deficiency PCD is a rare genetic disease caused by mutations in the SLC22A5 gene, which leads to dysfunction of the carnitine transporter OCTN2, thereby hindering the entry of carnitine from the blood into cells and the reabsorption of carnitine by the kidneys

It was found that heat shock protein beta-1 (HSPB1) can further reduce intracellular iron concentrations by inhibiting TRF1 expression, and so overexpressed HSPB1 can significantly inhibit ferroptosis 27

Journal of Pharmacology and Experimental Therapeutics, 329 , 1110 1116