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Older secretagogues like GHRP-6 and GHRP-2 also activated this pathway, but they came with significant side effects: hunger, cortisol spike, prolactin elevation

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The rise in calcium ions facilitates the fusion of growth hormone-containing vesicles with the cell membrane, allowing the release of growth hormone into the bloodstream

NDH at 42-47 mmol/mol or 6.0-6.4%), fasting plasma glucose (diabetes 7.0 mmol/L), lipid profiles, and thyroid function tests as clinically indicated

Cesinaro AM, Schirosi L, Bettelli S, et al