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Eight of 18 patients presented a partial response, with a median duration of response (DoR) of 4 months (range, 2 to 9) and a median PFS of 5 months (95% CI, 3 to 9) [24]

Primary cell cultures reveal greater heterogeneity, and their inherent limited replication potential necessarily implies the preservation of the in vivo characteristics, providing a more physiological model [81]

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