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Crajoinas RO, Polidoro JZ, Carneiro de Morais CP, Castelo-Branco RC, Girardi AC
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MC1R receptor variants in very fair-skinned individuals are less responsive to melanocortin signaling, requiring more sustained stimulation to switch from pheomelanin to eumelanin production
note that daily dosing is only for the activation phase of the GLOW protocol (weeks 1-4) , decreasing to 5x per week for the remodeling phase (weeks 5-8), and further reduced to 2-3x per week during maintenance (weeks 9-12)
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