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The risk of biliary disease has been examined in fewer studies, which may be because gallbladder emptying is impaired

For researchers managing the transition off treatment, the troubleshooting slow response and tirzepatide plateau management guides provide strategies for maximizing results during active treatment, which can improve long-term outcomes by establishing better metabolic baselines before discontinuation

Most involve a relatively small number of subjects, and few of the research teams seem to have actually published papers describing their methods and data

Eli Lilly's oral drug Orforglipron helped people who switched from an injectable GLP-1 RA maintain the majority of their weight loss for another year

The study recruited patients who had successfully lost at least 5% of their body weight over 72 weeks while on one of the two existing weight-loss jabs