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W.WeissmanI
It has been detected in central nervous system tissues, peripheral organs, and various biological fluids across multiple animal models, although its biosynthetic origin and precursor structure remain incompletely characterised
Specifically, downregulated heat shock protein A12A (HSPA12A) in hepatocytes increases glycolysis and lactate production, which leads to HMGB1 lactylation and exosomal secretion of hepatocytes, exacerbating hepatocyte damagemacrophage chemotaxis/activation
dal Maso, E
Unno, et al., Acute enhancement of non-rapid eye movement sleep in rats after drinking water contaminated with cadmium chloride
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