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Lower Risk Across All Key Outcomes with GLP-1RA Compared with DPP-4 inhibitors, GLP-1RA use was associated with significantly lower risks of MACE (hazard ratio [HR]: 0.66), VTE (HR: 0.49), kidney disease progression (HR: 0.77), and all-cause mortality (HR: 0.26)
In patients with type 2 diabetes and rheumatoid arthritis, retrospective analyses suggest that GLP-1 receptor agonists may provide glycemic and weight benefits comparable to those seen in the general diabetes population, without apparent increases in rheumatoid arthritis flares or complications, though these observations are based on small samples
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